Embark your cruise in Porto. Gather on board tonight for your Welcome Aboard Wine Toast. (D)

The colorful city of Porto blends the best of old and new, which you can discover on an escorted tour of the historic quarter, a UNESCO World Heritage Site, including the Cathedral, one of the city’s oldest monuments; and the São Bento Railway Station, known for its blue and white tile panels depicting scenes from Portuguese history. You’ll also enjoy a tasting of Port, Portugal’s most renowned contribution to the world of wine at Graham’s Winery. Prefer to get more active, you can hike to Graham’s Winery, offering magnificent views over the Douro River. Later in the day, set sail to Entre-os-Rios where you’ll be treated to a lovely wine and cheese tasting at Quinta da Avelada, one of the best wine producing estates in the Vinho Verde region. Quinta de Aveleda is also known for its lovely gardens, which are home to a thatched house for geese, peacocks and graceful swans.

Afterwards, travel to picturesque Lamego, home to one of the most important pilgrimage sites in all of Portugal, to see the Nossa Senhora dos Remédios (Sanctuary of Our Lady of Remedies). The shrine features a staircase of nearly 700 steps, beautifully decorated with white and blue tiles, which the more active adventurer will want to hike. Concluding both tours, you will have the opportunity to sample local traditional specialties, such as Bôlas de Lamego, bread filled with smoked ham; Presunto, a type of dry-cured ham; and Espumante, a Portuguese sparkling wine. You'll then go to the formal Episcopal Palace Museum. Venture to Quinta do Seixo, producers of some of the most traditionally made wine in the Douro region. An expert from the Sandeman Winery will take you on a tasting and private tour of the wine cellars, teaching you about the centuries-old winemaking methods. (B,L,D)

Spend time soaking up the beauty of the Douro River as you cruise to Barca d’Alva, where you will visit Castelo Rodrigo, a small fortified village perched high on a hilltop with centuries-old walls, steep narrow streets and fantastic views. You can also opt to hike up to the village should you wish a more active exploration. While here, taste some delicious locally grown produce. (B,L,D)

Drive to Salamanca, a UNESCO World Heritage Site. Built of golden sandstone, Salamanca is known as a “living museum,” and you will have an opportunity to step back in time to the Middle Ages during your escorted tour, which includes the city’s elegant university buildings, the twin-towered Cathedral, the intriguingly decorated House of Shells and Plaza Mayor. (B,L,D)

Savor an exclusive lunch at Quinta de Avessada. Later in the day, visit the Baroque-style Palacio de Mateus and its gardens, located in the beautiful Trás-os-Montes region. Inside the house you’ll see exhibits of religious images and beautiful furnishings, paintings and a ceiling of intricately carved wood. The gardens here are considered some of the most beautiful in Portugal. (B,L,D)

Visit Guimarães, one of the most historic towns in Portugal and a UNESCO World Heritage Site. The birthplace of Portugal’s first king, Guimarães claims to be “the cradle of the nation” and boasts a historic center that is one of the most attractive and best preserved in all of Portugal. You also have the choice to take a short journey to a nearby coastal town for the “Tastes of Matosinhos” tour where you’ll visit a traditional restaurant serving Pataniscas, a traditional Portuguese cod fish cake, and other typical regional snacks. (B,L,D)

Your cruise comes to an end as you prepare for your homeward flight. (B)

Arrive in Lisbon and check in to your hotel.

One of Europe’s most beautiful cities, Lisbon, stretches across several hills along the Tagus River. On your guided tour, you’ll see Belem Tower, a fortified four-story tower made of limestone, and visit the late Gothic Jerónimos Monastery, the burial place of many Portuguese kings and heroes. You will also taste a typical Portuguese pastry, Pastéis de Belém, before going to Discoveries Monument, built in honor of Portugal’s greatest maritime explorers. (B)

Enjoy a morning excursion to Serra de Sintra, one of the loveliest mountain villages in Portugal and a favorite summer residence of the Portuguese royal family for more than 500 years. Long an inspiration for artists and poets, Lord Byron once called it “perhaps the most delightful village in Europe.” High up on a rocky peak, you will tour the Castelo da Pena, a wonderful fairytale castle dating back to Portugal’s Romantic period. Afterwards, enjoy a wine tasting or free time on your own. (B)

Check out of your hotel and board a high-speed train to Porto to embark on your ship. Later in the evening, enjoy a welcome aboard wine toast. (B,D)

The colorful city of Porto blends the best of old and new, which you can discover on an escorted tour of the historic quarter, a UNESCO World Heritage Site, including the Cathedral, one of the city’s oldest monuments; and the São Bento Railway Station, known for its blue and white tile panels depicting scenes from Portuguese history. You’ll also enjoy a tasting of Port, Portugal’s most renowned contribution to the world of wine at Graham’s Winery. Prefer to get more active, you can hike to Graham’s Winery, offering magnificent views over the Douro River. Later in the day, set sail to Entre-os-Rios where you’ll be treated to a lovely wine and cheese tasting at Quinta da Avelada, one of the best wine producing estates in the Vinho Verde region. Quinta de Aveleda is also known for its lovely gardens, which are home to a thatched house for geese, peacocks and graceful swans.

Afterwards, travel to picturesque Lamego, home to one of the most important pilgrimage sites in all of Portugal, to see the Nossa Senhora dos Remédios (Sanctuary of Our Lady of Remedies). The shrine features a staircase of nearly 700 steps, beautifully decorated with white and blue tiles, which the more active adventurer will want to hike. Concluding both tours, you will have the opportunity to sample local traditional specialties, such as Bôlas de Lamego, bread filled with smoked ham; Presunto, a type of dry-cured ham; and Espumante, a Portuguese sparkling wine. You'll then go to the formal Episcopal Palace Museum. Venture to Quinta do Seixo, producers of some of the most traditionally made wine in the Douro region. An expert from the Sandeman Winery will take you on a tasting and private tour of the wine cellars, teaching you about the centuries-old winemaking methods. (B,L,D)

Spend time soaking up the beauty of the Douro River as you cruise to Barca d’Alva, where you will visit Castelo Rodrigo, a small fortified village perched high on a hilltop with centuries-old walls, steep narrow streets and fantastic views. You can also opt to hike up to the village should you wish a more active exploration. While here, taste some delicious locally grown produce. (B,L,D)

Drive to Salamanca, a UNESCO World Heritage Site. Built of golden sandstone, Salamanca is known as a “living museum,” and you will have an opportunity to step back in time to the Middle Ages during your escorted tour, which includes the city’s elegant university buildings, the twin-towered Cathedral, the intriguingly decorated House of Shells and Plaza Mayor. (B,L,D)

Savor an exclusive lunch at Quinta de Avessada. Later in the day, visit the Baroque-style Palacio de Mateus and its gardens, located in the beautiful Trás-os-Montes region. Inside the house you’ll see exhibits of religious images and beautiful furnishings, paintings and a ceiling of intricately carved wood. The gardens here are considered some of the most beautiful in Portugal. (B,L,D)

Visit Guimarães, one of the most historic towns in Portugal and a UNESCO World Heritage Site. The birthplace of Portugal’s first king, Guimarães claims to be “the cradle of the nation” and boasts a historic center that is one of the most attractive and best preserved in all of Portugal. You also have the choice to take a short journey to a nearby coastal town for the “Tastes of Matosinhos” tour where you’ll visit a traditional restaurant serving Pataniscas, a traditional Portuguese cod fish cake, and other typical regional snacks. (B,L,D)

Your cruise comes to an end as you prepare for your homeward flight. (B)